LIVE TO 100
Eat well, eat fermented, and take supplements that strengthen your microbiome.
Maybe then you will live especially long, just like the lowly naked-mole rat.
The naked mole-rat shows few age-related degenerative changes, displays an elevated tolerance to oxidative stress, and its fibroblasts have shown resistance to heavy metals, DNA damaging agents, chemotherapeutics and other poisonous chemicals. Moreover, this mammals show remarkably small susceptibility to both spontaneous cancer and induced tumorigenesis. These features of the naked mole-rat are maintained throughout their long lifespan, making this rodent a putative animal example of impressively prolonged “healthspan”.
Why does the lowly naked mole-rat live so long?
Possibly because of their non-diverse breeding yet very diverse microbiome.
Moreover, the within-colony low genetic diversity (possibly due to the high inbreeding rate), the climatologically stable underground habitats, and the constant diet (mainly tubers and other underground plant storage organs), make the naked mole-rat a unique model for studying the microbiota-host interaction, focusing on the ability of the gut microbes to contribute to health maintenance during aging.
You may also wish to take TA65, though it is fairly expensive.
What is TA65? The brand name for Cycloastragenol.
Cycloastragenol is a molecule isolated from various species in the genus Astragalus that is purported to have telomerase activation activity.
TA65 might — might — offer anti-aging relief, via the aforementioned telomerase activation activity, and possibly without increasing your cancer risk.
It’s all about them telomeres.
A 2010 Harvard study revealed: “telomeres are there as a built-in limit to how many times a cell can divide itself – they’re part of the built-in biological clock that causes aging, body deterioration and death.”
(Harard) gave the mice injections to re-activate the telomerase enzyme – expecting to see the aging process slow down to normal levels. Instead, they watched in astonishment as the mice appeared to age backwards, their withered organs repairing themselves even to the point of new neurons beginning to sprout in their brains.
In essence, repairing the telomeres seemed to be able to reverse the aging process and make the mice physiologically younger, despite already suffering the ravages of age.
LIVE TO 500
Quick! Support human clinical trials for senolytic drugs.
As we age, we accumulate senescent cells, which are damaged cells that resist dying off but stay in our bodies. They can affect other cells in our various organs and tissues. Senolytic drugs are agents capable of killing problem-causing senescent cells in your body without harming your normal, healthy cells.
Refresher: “It has been proposed that senescent cells—damaged cells that have lost the ability to divide—drive the deterioration that underlies aging and age-related diseases.”
This struck me. Via Matthew, chapter 8:
When he was come down from the mountain, great multitudes followed him. And, behold, there came a leper and worshipped him, saying, Lord, if thou wilt, thou canst make me clean. And Jesus put forth his hand, and touched him, saying, I will; be thou clean. And immediately his leprosy was cleansed.
And when Jesus was come into Peter’s house, he saw his wife’s mother laid, and sick of a fever. And he touched her hand, and the fever left her: and she arose, and ministered unto them.
The Bible is a makers guide.
There are no doubt reasons for this far beyond the bounds of my understanding.
Might one such reason be this: when humans achieve the totality of the magic in the Bible, then we become worthy? Worthy of everlasting life?
Back to the literal healing power of touch. Are we close to altering another human’s well-being with a touch? Probably:
Music influences our perception of touch. “We have observed that the sexier we perceive music, the sexier we also perceive touch that is administered simultaneously”, study leader Tom Fritz explains.
The neuroscientists (at Max Planck Institute for Human Cognitive and Brain Sciences) achieved these new insights with the help of a clever experimental setup that involved a robot administering incognito touches: Study participants placed their forearm through a curtain where it was stroked by a controlled robot movement. At the same time they listened to pieces of music, which they later evaluated on a scale of being “not at all sexy” and “extremely sexy”.
In one of their experiments that involved a human assistant they found that the sexiness of music is transferred to the touch experience. Here the participants thought they were touched by a person, but were in reality touched by the robot. Interestingly, when the participants knew in advance that they would be stroked by a robot rather than by a person in the experiment, the music still had the same effect regarding sexiness of touch. Using a robot’s automatically controlled brush did not just ensure that the duration and intensity of contact was always the same. It could additionally demonstrate that the observed transfer effects from music to touch are based on very basal mechanisms–rather than by a person’s imagination to be touched by a person of a certain sex or attractiveness who listens to the same music.
“Music seems to change our perception of touch. Certain features seem to be transferred from music to touch”, says Fritz.
A sound — or words — a touch, and we are changed.