THE BIBLE IS A MAKERS GUIDE

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LIVE TO 100

You are among many.

23andMe, the Mountain View-based genetic testing and analysis company, is raising close to $200 million.

Previously, 23andMe raised over $230 million, dating back to 2007. Google, Genentech, NEA and Johnson & Johnson are amongst its prior investors.

Rich techies are aware that you want to live to 100, and are willing to risk other’s billions to make that happen.

You are among many.

Diets fail.

A wide range of dietary approaches (low-fat to low-carbohydrate/ketogenic, and all points between) can be similarly effective for improving body composition, and this allows flexibility with program design. To date, no controlled, inpatient isocaloric diet comparison where protein is matched between groups has reported a clinically meaningful fat loss or thermic advantage to the lower-carbohydrate or ketogenic diet. The collective evidence in this vein invalidates the carbohydrate-insulin hypothesis of obesity. However, ketogenic diets have shown appetite-suppressing potential exemplified by spontaneous caloric intake reductions in subjects on ketogenic diets without purposeful caloric restriction. Athletic performance is a separate goal with varying demands on carbohydrate availability depending on the nature of the sport. Carbohydrate restriction can have an ergolytic potential, particularly for endurance sports. Effects of carbohydrate restriction on strength and power warrant further research.

There are so many studies, so many body types, so many diets, so much conflicting, confusing advice, and yet so much that doesn’t work for you.

Eat the best calories.

As you define this.

That will work.


LIVE TO 500

You are among many.

A new generation of transhumanists is emerging.

Three years ago, we had only around 400 members, but today we have over 10,000 members,” says Amanda Stoel, co-founder and chief administrator of Facebook group Singularity Network, one of the largest of hundreds of transhumanist-themed groups on the web.


LIVE FOREVER

You are among many.

You hear that radical longevity is simply not possible. Still, you believe.

Researchers from the Albert Einstein College of Medicine in New York released a study that identified a supposed limit to the maximum lifespan of human beings. In their study published in the journal Nature, the researchers pegged maximum human lifespan to an average of 115 years.

Does this mean living to 500 — or forever — is impossible?

Perhaps we are simply doing it wrong?

Jesus: “No man putteth a piece of new cloth unto an old garment, for that which is put in to fill it up taketh from the garment, and the rent is made worse. Neither do men put new wine into old bottles: else the bottles break, and the wine runneth out, and the bottles perish: but they that put new wine into new bottles, and both are preserved.”

So much of what we hear about radical life extension, living for hundreds of years, maybe forever, is putting new — blood, organs, stem cells, bionics — into our (old) body. Is this wrong? Will we have to make our body new, our mind new, so that we may live forever?

TOUCH

LIVE TO 100

Eat well, eat fermented, and take supplements that strengthen your microbiome. 

Maybe then you will live especially long, just like the lowly naked-mole rat.

The naked mole-rat shows few age-related degenerative changes, displays an elevated tolerance to oxidative stress, and its fibroblasts have shown resistance to heavy metals, DNA damaging agents, chemotherapeutics and other poisonous chemicals. Moreover, this mammals show remarkably small susceptibility to both spontaneous cancer and induced tumorigenesis. These features of the naked mole-rat are maintained throughout their long lifespan, making this rodent a putative animal example of impressively prolonged “healthspan”.

Why does the lowly naked mole-rat live so long?

Possibly because of their non-diverse breeding yet very diverse microbiome.

Moreover, the within-colony low genetic diversity (possibly due to the high inbreeding rate), the climatologically stable underground habitats, and the constant diet (mainly tubers and other underground plant storage organs), make the naked mole-rat a unique model for studying the microbiota-host interaction, focusing on the ability of the gut microbes to contribute to health maintenance during aging.

You may also wish to take TA65, though it is fairly expensive.

What is TA65? The brand name for Cycloastragenol.

Cycloastragenol is a molecule isolated from various species in the genus Astragalus that is purported to have telomerase activation activity.

TA65 might — might — offer anti-aging relief, via the aforementioned telomerase activation activity, and possibly without increasing your cancer risk.

It’s all about them telomeres.

A 2010 Harvard study revealed: “telomeres are there as a built-in limit to how many times a cell can divide itself – they’re part of the built-in biological clock that causes aging, body deterioration and death.”

(Harard) gave the mice injections to re-activate the telomerase enzyme – expecting to see the aging process slow down to normal levels. Instead, they watched in astonishment as the mice appeared to age backwards, their withered organs repairing themselves even to the point of new neurons beginning to sprout in their brains.

In essence, repairing the telomeres seemed to be able to reverse the aging process and make the mice physiologically younger, despite already suffering the ravages of age.


LIVE TO 500

Quick! Support human clinical trials for senolytic drugs.

As we age, we accumulate senescent cells, which are damaged cells that resist dying off but stay in our bodies. They can affect other cells in our various organs and tissues. Senolytic drugs are agents capable of killing problem-causing senescent cells in your body without harming your normal, healthy cells.

Refresher: “It has been proposed that senescent cells—damaged cells that have lost the ability to divide—drive the deterioration that underlies aging and age-related diseases.”


LIVE FOREVER

This struck me. Via Matthew, chapter 8:

When he was come down from the mountain, great multitudes followed him. And, behold, there came a leper and worshipped him, saying, Lord, if thou wilt, thou canst make me clean. And Jesus put forth his hand, and touched him, saying,  I will; be thou clean. And immediately his leprosy was cleansed.

And when Jesus was come into Peter’s house, he saw his wife’s mother laid, and sick of a fever. And he touched her hand, and the fever left her: and she arose, and ministered unto them.

The Bible is a makers guide.

There are no doubt reasons for this far beyond the bounds of my understanding.

Might one such reason be this: when humans achieve the totality of the magic in the Bible, then we become worthy? Worthy of everlasting life?

Back to the literal healing power of touch. Are we close to altering another human’s well-being with a touch? Probably:

Music influences our perception of touch. “We have observed that the sexier we perceive music, the sexier we also perceive touch that is administered simultaneously”, study leader Tom Fritz explains.

The neuroscientists (at Max Planck Institute for Human Cognitive and Brain Sciences) achieved these new insights with the help of a clever experimental setup that involved a robot administering incognito touches: Study participants placed their forearm through a curtain where it was stroked by a controlled robot movement. At the same time they listened to pieces of music, which they later evaluated on a scale of being “not at all sexy” and “extremely sexy”.

In one of their experiments that involved a human assistant they found that the sexiness of music is transferred to the touch experience. Here the participants thought they were touched by a person, but were in reality touched by the robot. Interestingly, when the participants knew in advance that they would be stroked by a robot rather than by a person in the experiment, the music still had the same effect regarding sexiness of touch. Using a robot’s automatically controlled brush did not just ensure that the duration and intensity of contact was always the same. It could additionally demonstrate that the observed transfer effects from music to touch are based on very basal mechanisms–rather than by a person’s imagination to be touched by a person of a certain sex or attractiveness who listens to the same music.

“Music seems to change our perception of touch. Certain features seem to be transferred from music to touch”, says Fritz.

A sound — or words — a touch, and we are changed.

Believe.

FOURTEEN

LIVE TO 100

Break your physical — and emotional — addition to carbs.

The Lancet:

We documented 5796 deaths and 4784 major cardiovascular disease events. Higher carbohydrate intake was associated with an increased risk of total mortality

Intake of total fat and each type of fat was associated with lower risk of total mortality.

Total fat and types of fat were not associated with cardiovascular disease, myocardial infarction, or cardiovascular disease mortality, whereas saturated fat had an inverse association with stroke. Global dietary guidelines should be reconsidered in light of these findings.

We got the truth completely wrong.


LIVE TO 500

To remain alive for 500 years we will likely require regularized, if artificial, stimulation of our brain, coupled with nerve, flesh and muscle regenerative technologies.

Scientists are making remarkable progress at using brain implants to restore the freedom of movement that spinal cord injuries take away.

Progress:

(Dr Gregoire) Courtine wanted to prove he could get the monkey walking again. To do it, he and colleagues had installed a recording device beneath its skull, touching its motor cortex, and sutured a pad of flexible electrodes around the animal’s spinal cord, below the injury. A wireless connection joined the two electronic devices.

The result: a system that read the monkey’s intention to move and then transmitted it immediately in the form of bursts of electrical stimulation to its spine. Soon enough, the monkey’s right leg began to move. Extend and flex. Extend and flex. It hobbled forward.

Using monkeys is unsettling, I know, though I suspect that as the world replaces real meat with fake meat, animals will become more widely used as test vehicles for radical life extension techniques.


LIVE FOREVER

“So all the generations from Abraham to David are fourteen generations; and from David until the carrying away into Babylon are fourteen generations; and from the carrying away into Babylon unto Christ are fourteen generations.”

I know. You can’t possibly allow yourself to believe in…Jesus Christ. I am not here to convince you otherwise.

Only to remind.

No rational, honest, intelligent, considered human could possibly believe:

“When as his mother Mary was espoused to Joseph, before they came together, she was found with child of the Holy Ghost.”

And yet, virgin birth — implanting a fertilized egg into a woman — is now so common as to be forgotten.

But the common is not what fascinates me, rather that to come.

Behold, the angel of the Lord appeared unto him in a dream, saying, Joseph, thou son of David, fear not to take unto thee Mary thy wife: for that which is conceived in her is of the Holy Ghost.

And…

Being warned of God in a dream that they should not return to Herod, (the wise men) departed into their own country another way.

And…

When they were departed, behold, the angel of the Lord appeareth to Joseph in a dream, saying, Arise, and take the young child and his mother, and flee into Egypt.

When do we still mortals possess this similarly fantastical technology? Inserting dreams into another’s brain, just as we insert the fertilized egg into the virgin?

Could this be a means of ‘living’ forever?

Our words and wisdom, voice and image inserted into another’s dreams.

Until we conquer physical death, this may have to do.

Not good enough?

Agreed.

But imagine those already dead, yet always with you, able to literally appear before you, speak to you — while you sleep. That’s not nothing.

EGGS

LIVE TO 100

Can’t live forever if you don’t reach 100. But reach 100 and you might — just might — be alive for when we’ve all learnt enough and dreamt enough and created enough, each of which we affix to our bodies and minds, enabling us to live possibly to age 500.

Stop disbelieving!

Reminder: at any moment you can speak with someone on the opposite side of the world.

The fantastical is made real at an accelerating rate. Yawn.

To help get to 100, take the top anti-aging supplements and do these life extension hacks.

Too much information? Start here: Lose the belly fat. Exercise regularly. Consume greens and healthy fats. Consider a fast day every week, fortnight or month.


LIVE TO 500

Many of us won’t make it, but I suspect that those who do reach 500 won’t simply be “test tube babies.” In fact, they will come from artificial insemination of artificial gametes.

These artificial gametes will no doubt be pre-programmed for maximum lifespan.

Scientists are trying to manufacture eggs and sperm in the laboratory.

Progress toward making “artificial gametes” has been accelerating. In Japan, mice were born from eggs scientists had manufactured in a dish from a tail cell. Chinese scientists later claimed they had determined the exact sequence of molecular signals required to make mouse sperm. So far, the exact biochemical formula for prompting a stem cell to mature into functional human eggs or sperm remains out of reach.


LIVE FOREVER

You hear the tragic tales of children dying, of a woman — perhaps even in America, perhaps even in the (early) 20th century — giving birth to 9 children, 3 of them dead before the age of 5.

Absolutely devastating.

But what of when we live to 500?

Can we remember each our children, those living, those dead, when we are 64 x 10?

The average age of a father of a newborn in the United States increased from 27.4 years old to 30.9 years old between 1972 and 2015, found Stanford University School of Medicine researchers led by Dr. Michael Eisenberg.

This matters…

Men who want to become fathers might want to think about the implications of their choices, Eisenberg suggests. “There is data that a man’s fertility declines with age,” Eisenberg, an assistant professor of urology, wrote in an email. “As such, it may make sense to not wait too long as it may be more difficult to conceive. In addition, there are some potential risks to children.”

We will have to change this.

At age 247, some men will want a baby.

But if they recklessly chose not to freeze their sperm before turning 125? What then? Assuming artificial gametes aren’t reality, or if the man wants the child created from his long-ago self, say when he was no more than 60?

Probably society will exert tremendous pressure on men to ensure they can ‘have’ children at any age, any stage of life, sort of like how women today must think about their appearance whenever they go out.

Views on life and death, and the creation of life and the taking of death, are on the cusp of profound change.

Esther, chapter 9: “Thus the Jews smote all their enemies with the stroke of the sword, and slaughter, and destruction, and did what they would unto those that hated them.”

But what happens when we humans can bring the slain humans back to life?

Or when human life extends into the hundreds of years?

Always remember: we will not achieve radically long lifespan in isolation. The hard parts, the messy bits, these won’t be about the drugs and supplements and prosthetics and electronics we weave into our flesh. It will be everything else.

CHEESE

LIVE TO 100

This study suggests that farming — highly organized, large-scale agriculture and cheesemaking — made us smaller + weaker than previous humans.

Researchers then studied over 1,000 skulls and jaws from pre-industrial communities across the world who were either hunter gatherers or farmers. They found that the temporalis –  a part of a major chewing muscle – shrank and changed position as groups changed their diet, leading the upper jaw to become shorter and the lower jaw smaller.

Agriculture changed not only human culture and lifeways, but human biology as well.

‘The largest changes in skull morphology were observed in groups consuming dairy products, suggesting that the effect of agriculture on skull morphology was greatest in populations consuming the softest food.

And…

An earlier study by The University of Cambridge suggested human skeletons became lighter and more fragile after the invention of agriculture due to us switching from foraging to farming. The bone strength of human hunter-gatherers from around 7,000 years ago was comparable to modern orangutans. But farmers from the same area over 6,000 years later had lighter, weaker bones.

How much lesser is our current diet making us?

Eat better.

The libertarian candidate for governor of California believes that we will be able to upload our “consciousness” into the “cloud” — within a generation or so.

(Zoltan Istvan) cintends to divert trillions of dollars into life-extending technologies – robotic hearts, artificial exoskeletons, genetic editing, bionic limbs and so on – in the hope that each Californian man, woman and AI (artificial intelligence) will eventually be able to upload their consciousness to the Cloud and experience digital eternity.

Crazy?

Probably.

Like how 30 years ago those crazy people on talk radio were talking about nazis and socialists battling it out on the streets of America in the 21st century.

Then there’s this:

A company set up by Elon Musk to develop advanced biotechnology enhancements for the human brain has raised $27m from 12 investors, according to a Securities and Exchange Commission filing.  Neuralink could be seeking as much as $100m within the next 12 months, the filing appears to state.

The firm is investigating the use of electronic devices that can be embedded in the brain to improve human performances in specific areas, such as memory.

Smart, rich people are no doubt happy to spend at least millions to extend their life. But they also see a very real financial opportunity by helping at least millions more to do the same.

LIVE TO 500

A Cedars-Sinai study reveals how humans will stay young for…close to ever.

Old hearts may find new life, according to a new study, which shows that stem cells taken from younger hearts can be used to reverse the aging process. This could potentially cause older hearts to act and perform like younger ones.

But we won’t just be forever young.

We will be profoundly different.

For example, Rutgers University has developed a prototype nano-sized device that can be used to give a robotic arm super strength.

Rutgers University-New Brunswick engineers have discovered a simple, economical way to make a nano-sized device that can match the friendly neighborhood Avenger, on a much smaller scale. Their creation weighs 1.6 milligrams (about as much as five poppy seeds) and can lift 265 milligrams (the weight of about 825 poppy seeds) hundreds of times in a row.

Its strength comes from a process of inserting and removing ions between very thin sheets of molybdenum disulfide (MoS2), an inorganic crystalline mineral compound. It’s a new type of actuator – devices that work like muscles and convert electrical energy to mechanical energy.

Something like this will make its way into bionic limbs which will then make their way into humans.

Then 400 years will pass and just imagine what humans will be like.

LIVE FOREVER

2 Corinthians 5:17: “Therefore if any man be in Christ, he is a new creation. Old things are passed away; behold, all things are become new.”

Maybe this verse is not a metaphor, nor a declaration of faith. Maybe it’s an acknowledgement that humans are right to be fully remade.

Do not fear a very long life. Or change.

FAT

Live to 100 

Do not fear fat. 

Those with the highest intake of dietary fat (35 percent of daily calories) were 23 percent less likely to have died during the study period than those with the lowest fat intake (10 percent of calories).

The rates of various cardiovascular diseases were essentially the same across fat intake, while strokes were less common among those with a high fat intake.

Eat plants, seeds, lean protein, and quality fats. You know this, whether you choose to do this or not.

 Live to 500

Re-define the best parts of the pig.

Scientists at a Cambridge startup co-founded by Harvard geneticist George Church said Thursday that they had used gene-editing technology to create pigs that are free of harmful viruses, an important step toward transplanting whole pig organs into humans.

In a generation, maybe billions of us will be deliberate vegetarians — thanks in large part to ‘lab grown’ fake meat.

Flesh, yucky!

But animals will still be raised, possibly in industrial-age farms, for spare and replacement human parts. This may be necessary for humans to live extremely long lives.

Live Forever

We are meant to live hundreds of years, at least.

The Bible teaches quite plainly that the early patriarchs often lived to be nearly 1,000 years old and even had children when they were several hundred years old! Similar claims of long life spans are found in the secular literature of several ancient cultures (including the Babylonians, Greeks, Romans, Indians, and Chinese).

No, I am not asking that you believe in the Bible, nor even in God. That is for you. But our earliest ancestors, those capable of telling stories, told tales of humans living to 1,000, and our earliest ancestors capable of writing those stories down found them important enough to write them down, and all those that followed kept these stories alive, reprinting them for everyone, everywhere.

It is in us to strive to live at least for hundreds of years.


Accept that not all breakthroughs will come via traditional means. 

Billionaire techie Peter Thiel is backing a herpes vaccine trial outside the US, beyond the reach of the FDA.

The vaccine—a live but weakened herpes virus—was first tested in a 17-person trial on the Caribbean Island of St. Kitts without federal oversight or the standard human safety requirement of an institutional review board (IRB) approval. Biomedical researchers and experts have sharply rebuked the lack of safety oversight and slammed the poor quality of the data collected, which has been rejected from scientific publication. However, investors and those running the trial say it is a direct challenge to what they see as innovation-stifling regulations by the Food and Drug Administration.

I admire the FDA and our traditional clinical trials methodology.

I also know that to push radical life extension forward — fast enough — off-shore trials not approved by the FDA will barely raise an eyebrow.

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