Until the science advances, for now continue to think happy thoughts and tell yourself you’re much younger than your chronological age otherwise suggests:

Last week, a new study came out fingering the hypothalamus as locus of a clock that modulates aging.  This encourages those of us who entertain the most optimistic scenarios for anti-aging medicine.  Could it be that altering the biochemistry of one tiny control center might effect global rejuvenation?

Probably not. But, the idea is both enticing and truly profound.

A dream is to be able to reset the hands of the clock.  If we’re lucky, then changing the state of some metabolic subsystem will not just temper the rate at which we age, but actually restore the body to a younger state.  Most of the research in anti-aging medicine is still devoted to ways to engineer fixes for damage the body has allowed to accumulate; but I belong to a wild-eyed contingent that thinks the body can do its own fixing if we understand the signaling language well enough to speak the word “youth” in the body’s native biochemical tongue.

In the meantime, don’t stop taking fish oil supplements or exercising daily.

The latest study on “klotho” is another reminder that we need to uncover ways to reliably boost this important enzyme.


A single injection of a fragment of the longevity hormone klotho into both young and old mice improved spatial and working memory and strengthened connections between neurons in the hippocampus rapidly, and these cognitive benefits lasted for several weeks, according to a study published August 8 in Cell Reports.


Moreover, short-term treatment with the klotho fragment countered cognitive and motor deficits in mice with diseased brains.


High levels of the naturally occurring hormone klotho, which regulates multiple signaling pathways and cellular processes, are associated with longer lifespan in worms, mice, and humans.

How to increase klotho? Not sure. Probably sunlight, a healthy gut, meditation, a nightly glass of wine. It’s still not clear.

Continue to use your vote, voice, connections and pocketbook to lobby for life extension research, medicines, and technologies.

Slowing the aging process is especially good for the government’s bottom line! 

Age-related conditions are the leading causes of death and health-care costs. Reducing the rate of aging would have enormous medical and financial benefits.

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