Aspirin, one of the planet’s cheapest and most accessible medicines, is also tops in our supplement rankings.

Because it works.

Although it was originally used only for pain relief, aspirin is today used for everything from reducing risk of heart attacks and stroke to potentially reducing cancer risk.

This brief Smithsonian magazine write-up of aspirin makes me wonder if I should boost its ranking.

On this day in 1897, a German chemist named Felix Hoffman created a chemically pure and stable form of salicylic acid–otherwise known as the active ingredient in aspirin.

Using salicylic acid as a pain reliever is something that goes back for thousands of years. Four thousand years ago, Sumerians wrote about how the willow tree could be used for pain relief. “Both Chinese and Greek civilizations employed willow bark for medical use more than 2,000 years ago.”

Our mission is to help you live your longest — and for the cheapest.

Otherwise, you won’t.

That’s what nobody else tells you.

But we understand that hacking mortality is big business — and getting bigger. For example, British biotech billionaire Jim Mellon is one of several very rich people pouring money into (for-profit) drugs which may help increase lifespan. In this instance, the start-up Juvenescence.

The longevity industry, Mellon said recently, is destined to grow “into the world’s largest industry.” And he wants in.

Juvenescence will use “Artificial Intelligence” to help in the drug development process. We’ll track their efforts.

Another breathless post touting the magic of calorie restriction. I do not believe the vast majority of humans will ever voluntarily and continuously restrict their calories enough to achieve the most optimistic results.

In a second group of mice, who were on a diet of 30 per cent fewer calories for six months, it was found that energy was processed in a more stable way.

Researchers summarised that low calorie meals help the (mouse) body metabolise energy more efficiently, which leads to looking and feeling younger.

Try it, I give you no more than 10 days.

Calorie restriction in a pill, however…

We do not recommend any nootropics. 

Nootropics is the term used for supplements/pharmaceuticals that promise to enhance or in some way stimulate or improve your brain power.

This article does an excellent job explaining why — for now — you should steer clear of nootropics. In particular, this common sense declaration:

There shouldn’t be universally effective nootropics, for the same reason there’s no chemical you can pour on your computer to double its processing speed: evolution put a lot of work into making your brain as good as possible, and it would be silly if some random molecule could make it much better.

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