living your longest for the cheapest

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Eat curcumin. 

Curcumin scores high in our supplement rankings but why buy tablets when you can get curcumin from your food? It’s healthy and it’s delicious and it’s readily available (in tumeric).

It’s a powerful antioxidant that may help you maintain cholesterol levels already in the normal range, minimize oxidative stress, support brain health, and assist your gall bladder function.

Get a good night’s sleep. It may help you stave off Alzheimer’s.

Leading to a longer, happier life.

The proinflammatory aspects of chronic sleep restriction are well documented. Of particular importance to people at risk for (Alzheimer’s disease), some sleep characteristics are predictive of cognitive decline in older adults, such as excessive daytime sleepiness, frequent awakenings, and nighttime sleep durations less than 6.5 (hours).

Ponder the possibilities of living forever. 

Fine, pondering this won’t help you live longer, but it reveals a potential path toward human immortality.

The 2045 movement, founded by Russian billionaire Dmitry Itskov in 2011, aims to make humans immortal by transferring their personalities into a carrier superior to the human body. The movement’s ideology is “to create technologies enabling the transfer of a individual’s personality to a more advanced non-biological carrier, and extending life, including to the point of immortality.”


Eat that tomato paste, take your lycopene!

This comprehensive meta-analysis suggests that high-intakes or high-serum concentration of lycopene are associated with significant reductions in the risk of stroke (26%), mortality (37%) and CVDs (14%).

Worldwide, cardiovascular diseases (CVDs) remains as the main cause of mortality. Observational studies supports an association between intake of tomato products or lycopene with a reduced CVDs risk.

Our mission here is to help everyone live their longest — for the cheapest. Lycopene helps achieve that mission.

Should you purchase a standard genetics test?

Our recommendation: save your money.

In the end, (the test) might give you a “yes” or “no” answer, or sometimes you’ll get a probability—a measure of how much your genes increase your risk of developing the disease. Then, it’s up to your doctor to figure out what these genes (in combination with your lifestyle, family history and other risk factors) mean for your health.

Our supplement rankings include the pill form of apple cider vinegar. Confession: I prefer the liquid version, which is significantly cheaper and quite tasty.

Apple cider vinegar in liquid form has been used for centuries for a wide variety of health conditions, from acne and acid reflux to gout and weight loss. Diabetics have found it helpful in regulating blood sugar, and heart patients have found that it lowers blood pressure.

That said, the evidence for apple cider vinegar’s health benefits and potential life extension properties are compelling.


Pterostilbene improves brain function, has cancer-fighting properties, and may lower blood pressure. Not surprisingly, we rank pterostilbene rather high in our supplement rankings.



Pterostilbene (terro-STILL-bean), found in blueberries, grapes, and in the bark of the Indian Kino Tree, has been used for centuries in Ayurvedic medicine. Pterostilbene and resveratrol are both stilbene compounds, closely related structurally, which gives them similar but not identical functions. Researchers have found that these two compounds work in a synergistic fashion to activate one’s “longevity genes.”

In fact, consider taking both pterostilbene and resveratrol.

Strongly re-consider undergoing any “alternative treatment” in fighting cancer.

People who choose alternative medicine over conventional treatment for their cancer are more likely to die from the disease.

The team identified 281 people with breast, prostate, lung and colorectal cancer who had opted for unproven treatments, shunning conventional approaches such as chemotherapy, radiotherapy and surgery. The team then compared the health outcomes of these people with 560 others who were similar to them in terms of age, race and disease, but instead underwent conventional treatment.

They found that people who took alternative medicine were two and half times more likely to die within five years of diagnosis. This is a low estimate, says Johnson, skewed by the fact that prostate cancer, for example, takes longer than that to develop into a life-threatening disease.

Millennials probably shouldn’t turn their backs on Baby Boomers: “cardiac stem cells from young hearts could rejuvenate old hearts.”

But, seriously, this news is not a mortality hack — yet — but it has near-term promise.

Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from the Cedars-Sinai Heart Institute.

“Our previous lab studies and human clinical trials have shown promise in treating heart failure using cardiac stem cell infusions,” said Eduardo Marbán, MD, PhD, director of the Cedars-Sinai Heart Institute and the primary investigator of the study. “Now we find that these specialized stem cells could turn out to reverse problems associated with aging of the heart.”


More money (and science) behind the potential significant life extension benefits of NAD.

Underlying the wide-ranging benefits of calorie restriction…are sirtuins—a group of seven genes that appear to be very important in regulating the aging process.

Sirtuins can be activated by a lack of amino acids or of sugar, or through an increase in NAD. (The compound’s level in the body declines with age.)

Our ranking of NAD is here.

Balance your omega 6/omega 3 intake and you will probably live longer.

Total fat and saturated fat intake as a percentage of total calories has continuously decreased in Western diets, while the intake of omega-6 fatty acid increased and the omega-3 fatty acid decreased, resulting in a large increase in the omega-6/omega-3 ratio from 1:1 during evolution to 20:1 today.

This change in the composition of fatty acids parallels a significant increase in the prevalence of overweight and obesity.

Obesity significantly contributes to early death.

A more natural balance between omega 6 and omega 3 will likely spur a reduction in obesity.

DO NOT EAT THESE (or, at least cut back significantly):

In a study of different foods and the balance between omega-6 and omega-3 fats, the ten food items with the most negative Omega 3-6 score were:

  • soybean oil,-50;
  • mayonnaise, -46;
  • tub margarine, -39;
  • microwave popcorn,-37;
  • “Italian” salad dressing, -35;
  • potato chips, -29;
  • stick margarine, -28;
  • vegetable shortening, -28;
  • peanut butter, -24;
  • tortilla chip snacks, -24.

Omega 6:3 balance bonus! Do it, and you’ll likely be more sexually potent.


Don’t be lonely, live longer.

Social isolation, loneliness or living alone was each a significant factor contributing to premature death.  And each one of these factors was a more significant risk factor for dying than obesity.

Make friends! Visit your children. Spend time with your parents. Get a job, volunteer.

“The AARP estimates that 42.6 million Americans over the age of 45 are suffering from loneliness, with nearly one quarter of the population living alone.”

Take nattokinase.

We have added nattokinase to our supplement rankings. Though we rated it high on the “life extension potential” factor, we require more evidence of its efficacy before giving it a higher total score.

Learn more here:

Nattokinase is an enzyme (a protein that speeds up biochemical reactions) that is extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto.

Natto has been used as a folk remedy for diseases of the heart and circulatory system (cardiovascular disease) for hundreds of years. Nattokinase, the chemical in natto that is probably responsible for its effects.

Nattokinase is used for cardiovascular diseases including heart disease, high blood pressure, stroke, chest pain (angina), deep vein thrombosis (DVT), “hardening of the arteries” (atherosclerosis), hemorrhoids, varicose veins, poor circulation, and peripheral artery disease (PAD).

Buyer beware! Do not get taken in by the many marketing claims and clickbait headlines promising radically longer, better, more robust life — for a price.

The supplement industry’s market is as much as $37 billion a year, according to one estimate. Ads for supplements can be found on internet pop-up windows, on social media, in magazine pages, and on TV. They’re sold in corner health stores, pharmacies, and big grocery conglomerates.


Aspirin, one of the planet’s cheapest and most accessible medicines, is also tops in our supplement rankings.

Because it works.

Although it was originally used only for pain relief, aspirin is today used for everything from reducing risk of heart attacks and stroke to potentially reducing cancer risk.

This brief Smithsonian magazine write-up of aspirin makes me wonder if I should boost its ranking.

On this day in 1897, a German chemist named Felix Hoffman created a chemically pure and stable form of salicylic acid–otherwise known as the active ingredient in aspirin.

Using salicylic acid as a pain reliever is something that goes back for thousands of years. Four thousand years ago, Sumerians wrote about how the willow tree could be used for pain relief. “Both Chinese and Greek civilizations employed willow bark for medical use more than 2,000 years ago.”

Our mission is to help you live your longest — and for the cheapest.

Otherwise, you won’t.

That’s what nobody else tells you.

But we understand that hacking mortality is big business — and getting bigger. For example, British biotech billionaire Jim Mellon is one of several very rich people pouring money into (for-profit) drugs which may help increase lifespan. In this instance, the start-up Juvenescence.

The longevity industry, Mellon said recently, is destined to grow “into the world’s largest industry.” And he wants in.

Juvenescence will use “Artificial Intelligence” to help in the drug development process. We’ll track their efforts.

Another breathless post touting the magic of calorie restriction. I do not believe the vast majority of humans will ever voluntarily and continuously restrict their calories enough to achieve the most optimistic results.

In a second group of mice, who were on a diet of 30 per cent fewer calories for six months, it was found that energy was processed in a more stable way.

Researchers summarised that low calorie meals help the (mouse) body metabolise energy more efficiently, which leads to looking and feeling younger.

Try it, I give you no more than 10 days.

Calorie restriction in a pill, however…

We do not recommend any nootropics. 

Nootropics is the term used for supplements/pharmaceuticals that promise to enhance or in some way stimulate or improve your brain power.

This article does an excellent job explaining why — for now — you should steer clear of nootropics. In particular, this common sense declaration:

There shouldn’t be universally effective nootropics, for the same reason there’s no chemical you can pour on your computer to double its processing speed: evolution put a lot of work into making your brain as good as possible, and it would be silly if some random molecule could make it much better.


Marijuana raises your blood pressure and reduces your longevity. So says this Georgia State University study, and that absolutely floors me. Nonetheless, I think it’s conclusions are worth considering — at the least, don’t smoke (or chew or in other ways imbibe) marijuana any more than you feel is necessary.

People who smoke marijuana have a three times greater risk of dying from hypertension, or high blood pressure, than those who have never used the drug, scientists said on Wednesday. The risk grows with every year of use.

Cancer remains a confounding and deadly enemy. There’s evidence, albeit sketchy, that radically cutting carbs and regular fasting will help you avoid cancer, fight cancer, and possibly live longer.

(The linked article strikes me as long-winded cheerleading. Read it if you wish.)

Boosting brain plasticity? In mice? It just might work!

Oh, and if it does, there’s clear potential for boosting brain plasticity in humans. Which may not prolong your life by much, but should make your alive years better.

Like much of the rest of the body, the brain loses flexibility with age, impacting the ability to learn, remember, and adapt. Now, scientists at University of Utah Health report they can rejuvenate the plasticity of the mouse brain, specifically in the visual cortex, increasing its ability to change in response to experience. Manipulating a single gene triggers the shift, revealing it as a potential target for new treatments that could recover the brain’s youthful potential.

Believe in God? Awesome!

Attend church regularly? Excellent!

But do not allow these to reduce your focus on staying healthy.

For religiosity, significant associations occurred between greater religiosity and higher body weight in both cross-sectional and longitudinal studies. In particular, greater religiosity was significantly associated with higher body weight in bivariate analyses but less so in multivariate analyses.


Probably personal choice.

Evidence in seven studies suggested that health behaviours and psychosocial factors mediate religion–weight relationships.

In our proprietary supplement rankings, Basis does quite well. This profile of the company behind Basis, Elysium, suggests its a deserved ranking.

Basis is clinically proven to increase NAD+ levels.


The coenzyme NAD+ has, for years, been revered as “the fountain of youth” among the bio-hacker community—mostly for its ability to improve metabolism, fight aging at the cellular level, and reduce fatigue.

Any evidence?

In the company’s first round of clinical trials, Elysium conducted a double-blind study in which 120 participants between the ages of 60-80 were divided into three groups. The first group received the recommended daily dose of Basis (250 mg of Nicotinamide Riboside and 50 mg of Pterostilbene), the second group received double the recommended daily dose, and the third group received a placebo. After just four weeks, blood tests revealed that the first group’s baseline levels of NAD+ had increased by 40 percent—and sustained that increase for the remainder of the eight-week trial. Participants taking double-doses of Basis saw a 90 percent baseline increase, also sustained.

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